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Psychiatric Manifestations in Wilson’s Disease: A Cross-Sectional Analysis

Received September 7, 2006; revised December 1, 2006; accepted March 5, 2007. The authors are affiliated with the Department of Neurology and Psychiatry at the National Institute of Mental Health and Neurosciences (NIMHANS) in Bangalore, India. Address correspondence to Dr. A. B. Taly, Professor, Department of Neurology, NIMH and Neurosciences (NIMHANS), Hosur Road, Bangalore-560 029, Karnataka, India; abtaly{at}yahoo.com (e-mail).

Behavioral and psychiatric abnormalities in Wilson’s disease (WD) have a variable frequency and spectrum. This study involved evaluation of the psychiatric comorbidities in patients of Wilson’s disease, using structured clinical interview for DSM-IV Axis-I disorders (SCID). Among the 50 confirmed patients with Wilson’s disease recruited for this study, 12 patients (24%) fulfilled the diagnostic criteria for syndromic psychiatric diagnosis: bipolar affective disorder (18%), major depression (4%), and dysthymia (2%). Formal assessment of psychopathology in all patients with Wilson’s disease may have therapeutic significance.

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