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Treatment of Akinetic Mutism with Intramuscular Olanzapine: A Case Series

Received February 25, 2007; revised June 5, 2007; accepted June 15, 2007. The authors are affiliated with the Eastern Virginia Medical School, Department of Psychiatry, in Norfolk, Virginia. Address correspondence to Dr. David R. Spiegel, Eastern Virginia Medical School, Department of Psychiatry and Behavior Sciences, 825 Fairfax Ave., Norfolk, VA 23507; spiegedr{at}evms.edu (e-mail).

ABSTRACT

Akinetic mutism is a wakeful state of severe apathy and paucity of volitional movement. Evidence indicates a possible dopaminergic hypofunction within the anterior cingulate cortex. The authors present three cases of acute onset akinetic mutism successfully treated with intramuscular olanzapine.

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