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Prediction of Clinical Outcomes From rTMS in Depressed Patients With Lateral Visual Field Stimulation: A Replication

Received July 23, 2006; revised April 6, 2007; accepted April 10, 2007. Drs. Schiffer and Teicher are affiliated with the Department of Psychiatry at Harvard Medical School and the Developmental Biopsychiatry Research Program, McLean Hospital, in Belmont, Massachusetts. Mr. Glass and Ms. Lord are affiliated with the MindCare Centres in Vancouver, Canada. Address correspondence to Fredric Schiffer, M.D., The Developmental Biopsychiatry Research Program, McLean Hospital, 115 Mill St., Belmont, MA 02478; fschiffer{at}mclean.harvard.edu (e-mail).

The authors sought to replicate an earlier finding that baseline lateral visual field stimulation, a procedure shown to activate the contralateral hemisphere and induce affective changes, predicted the clinical outcomes of a 10-day course of left-sided rapid transcranial magnetic stimulation (rTMS). For 23 patients there was a significant 1-tailed Pearson correlation between the percent improvement in response to rTMS and their lateralized affective responses to lateral visual field stimulation. These correlations, across the whole group and within genders, were almost identical to those previously reported from 37 patients studied at a different site.

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