Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via Google Scholar Articles by Hara, E. Articles by Uchitomi, Y. Search for Related Content PubMed Citation Articles by Hara, E. Articles by Uchitomi, Y. Posttraumatic Stress Disorder Syndromes Secondary to General Medical Disorders

Hippocampal and Amygdalar Volumes in Breast Cancer Survivors with Posttraumatic Stress Disorder

Received March 20, 2007; revised May 16, 2007; accepted May 18, 2007. Dr. Hara is affiliated with the Section of Psychiatry and Behavioral Science at Tokyo Medical and Dental University Graduate School in Tokyo. Drs. Hara, Matsuoka, Hakamata, Nagamine, and Kim are affiliated with the Department of Adult Mental Health at NIMH, National Center of Neurology and Psychiatry, in Tokyo. Drs. Hara, Matsuoka, Hakamata, Nagamine, Inagaki, and Uchitomi are affiliated with the Psycho-Oncology Division at the Research Center for Innovative Oncology, National Cancer Center Hospital East, in Chiba, Japan. Dr. Inagaki is affiliated with the Center for Suicide Prevention at NIMH, National Center of Neurology and Psychiatry, in Tokyo. Dr. Imoto is affiliated with the Department of Surgery at Kyorin University School of Medicine in Tokyo. Dr. Murakami is affiliated with the PET Center at Dokkyo University School of Medicine in Tochigi, Japan. Address correspondence to Yosuke Uchitomi, M.D., Ph.D., Psycho-Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan; yuchitom{at}east.ncc.go.jp (e-mail).

Although smaller hippocampi and amygdalae were found in cancer survivors with intrusions, associations between cancer-related posttraumatic stress disorder (PTSD) and these volumes are unknown. The authors performed MRI volumetric analyses of these regions in 15 cancer survivors with PTSD, 15 cancer survivors without PTSD, and 15 healthy comparison subjects. The authors also examined the correlation between PTSD symptom scores of the Impact of Event Scale and these volumes in the PTSD group. These volumes were not significantly different among the groups, but the intrusion score was inversely associated with the hippocampal volume. Results suggest intrusions, not PTSD diagnosis, might be associated with hippocampal volume.

Get information about faster international access.

Privacy Policy

Copyright © 2008 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us