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Treatment for Late-Onset Obsessive-Compulsive Disorder with Parkinsonism

Received March 24, 2007; revised July 10, 2007; accepted July 23, 2007. Drs. Agarwal and Biswas are affiliated with the Department Of Psychiatry at Maulana Azad Medical College and G.B. Pant Hospital in New Delhi; Dr. Sadhu is affiliated with the Department Of Psychiatry, All India Institute of Medical Sciences in New Delhi. Address correspondence to A.L. Agarwal, M.D., D-5, M.A.M.C. Campus, New Delhi- 110002, India; dralagrawal{at}hotmail.com (e-mail).

Dysfunction of the basal ganglia and frontal subcortical structures occurs in both obsessive-compulsive disorder and parkinsonism. Treatment of obsessive-compulsive disorder with parkinsonism is a therapeutic challenge, especially in old age as selective serotonin reuptake inhibitors may aggravate motor symptoms and worsen clinical conditions. The authors present a series of patients with late onset obsessive-compulsive disorder demonstrating improvement in obsessive-compulsive disorder as well as parkinsonian signs.

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