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Depressed Mood and Memory Impairment Before and After Unilateral Posteroventral Pallidotomy in Parkinson’s Disease

Received February 22, 2007; revised June 11, 2007; accepted June 15, 2007. Drs. Dulay and Grossman are affiliated with the Department of Neurosurgery at the Methodist Hospital Neurological Institute in Houston, Tex.; Drs. Strutt, Jankovic, Lai, and York are affiliated with the Department of Neurology at Baylor College of Medicine; Dr. Levin is affiliated with the Department of Neurosurgery at Baylor College of Medicine in Houston, Tex.; Drs. Lai and York are affiliated with the Parkinson’s Disease Research, Education and Clinical Center, Michael E. DeBakey VA Medical Center in Houston, Tex. Address correspondence to Michele K. York, Ph.D., One Baylor Plaza, NB302, Houston, TX 77030; myork{at}bcm.edu (e-mail).

ABSTRACT

This study evaluated poor mood state as a moderator of changes in verbal recall ability from before to after unilateral posteroventral pallidotomy in 54 individuals with advanced Parkinson’s disease. Repeated-measures analysis of covariance (controlling for motor disease severity) indicated that left-posteroventral pallidotomy subjects with depressed mood performed more poorly on measures of verbal list learning and story recall compared to nondepressed subjects or right-posteroventral pallidotomy subjects with depressed mood both before and after surgery. The results suggest that depressed mood should be taken into account when interpreting memory test performance in Parkinson’s disease surgical candidates both before and after surgery.

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