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Neural Correlates of Automatic and Controlled Auditory Processing in Schizophrenia

Received April 2, 2007; revised July 2, 2007; accepted September 12, 2007. Drs. Morey, Inan, and Belger are affiliated with the Duke-UNC Brain Imaging and Analysis Center (BIAC), Duke University, in Durham, N.C.; Dr. Morey is also affiliated with the Department of Psychiatry and Behavioral Sciences at Duke University and with the Mental Illness Research Education and Clinical Center at the Durham VA Medical Center in Durham, N.C.; Dr. Mitchell is affiliated with the Eunice Kennedy Shriver Center, University of Massachusetts Medical School, in Waltham, Mass.; Dr. Inan was and Dr. Belger is affiliated with the Department of Psychiatry at the University of North Carolina at Chapel Hill; Dr. Lieberman is affiliated with the Department of Psychiatry, College of Physicians and Surgeons, at Columbia University in New York. Address correspondence to Rajendra A. Morey, M.D., Department of Psychiatry, Duke University, Box 3918, Durham, NC 27707; morey{at}biac.duke.edu (e-mail).

Individuals with schizophrenia demonstrate impairments in selective attention and sensory processing. The authors assessed differences in brain function between 26 participants with schizophrenia and 17 comparison subjects engaged in automatic (unattended) and controlled (attended) auditory information processing using event-related functional MRI. Lower regional neural activation during automatic auditory processing in the schizophrenia group was not confined to just the temporal lobe, but also extended to prefrontal regions. Controlled auditory processing was associated with a distributed frontotemporal and subcortical dysfunction. Differences in activation between these two modes of auditory information processing were more pronounced in the comparison group than in the patient group.

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