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Long-Term Follow-Up Study of Patients With Refractory Obsessive-Compulsive Disorder

Received September 18, 2007; accepted November 26, 2007. Dr. Ross is affiliated with the Department of Adult Psychiatry at New York University; Drs. Fallon, Feinstein, and Liebowitz are affiliated with the Department of Psychiatry and the New York State Psychiatric Institute; Dr. Petkova is affiliated with the Department of Child and Adolescent Psychiatry at New York University. Address correspondence to Stephen Ross, M.D., 462 First Ave., NBV 20E7, New York, NY 10016; Stephen.ross{at}nyumc.org (e-mail).

The authors prospectively followed patients with treatment-resistant obsessive-compulsive disorder (OCD). Between 1988 and 1995, 56 patients with a history of inadequate response to oral clomipramine received 14 infusions of intravenous clomipramine. The follow-up period ranged from 4 to 11 years after treatment. Of the 44 subjects interviewed at follow-up, 70.5% had current OCD and 29.5% had sub-threshold OCD. Almost half reported feeling much improved or very much improved compared to their state prior to treatment with intravenous clomipramine.

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