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Clinical and Diagnostic Features of Delayed Hypoxic Leukoencephalopathy

Received July 13, 2007; revised September 10, 2007; accepted September 17, 2007. Drs. Shprecher and A.G. Smith are affiliated with the Department of Neurology at the University of Rochester in New York; Drs. Flanigan, A.G. Smith, S.M. Smith, Schenkenberg, and Steffens are affiliated with the Department of Neurology at the University of Utah Medical Center in Salt Lake City, Utah; Dr. Flanigan is also affiliated with the Departments of Pathology and Human Genetics at the University of Utah Medical Center in Salt Lake City. Address correspondence to David Shprecher, D.O., University of Rochester, Department of Neurology, 1351 Mt. Hope Ave, Suite 100, Rochester, NY 14620-3917; David_Shprecher{at}urmc.rochester.edu (e-mail).

Delayed hypoxic leukoencephalopathy is an underrecognized syndrome of delayed demyelination, which is important to consider when delayed onset of neuropsychiatric symptoms follows a hypoxic event. The authors describe clinical and diagnostic features of three such cases, review the pathophysiology of delayed hypoxic leukoencephalopathy, and discuss features which may help distinguish it from toxic leukoencephalopathy.

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