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Hippocampal Volumes in First-Episode Psychosis

Received May 14, 2007; revised October 9, 2007; accepted December 10, 2007. Dr. Verma, Ms. Poon, Dr. Subramaniam, Dr. Sim, and Prof. Chong are affiliated with the Institute of Mental Health/Woodbridge Hospital, Singapore; Dr. Sitoh and Ms. Ho are affiliated with the Department of Neuroradiology, National Neuroscience Institute, Singapore; Dr. Chan is affiliated with the Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore. Address correspondence to Swapna Verma, M.B.B.S., M.D. (Psychiatry), Department of Early Psychosis Intervention, Institute of Mental Health/ Woodbridge Hospital, 10 Buangkok View, Singapore 539 747, Singapore; Swapna_VERMA{at}imh.com.sg (e-mail).

Studies have shown that patients with schizophrenia have smaller hippocampi than healthy comparison subjects. There are, however, inconsistencies regarding the relationship between clinical characteristics and topographical differences in hippocampal volumetry. The authors investigated hippocampal volumes in minimally treated patients with first-episode schizophrenia spectrum disorders, relative to comparison subjects. Thirty-nine consecutive patients and 29 matched comparison subjects were scanned using 1.5 tesla MR system. Patients had significantly smaller right anterior, right, and anterior hippocampal volumes than comparison subjects. There was a gender by diagnosis effect: female patients showed significantly smaller anterior and right hippocampal volumes than female comparison subjects, an effect not seen in male patients. Our results suggest that smaller hippocampal volumes are present even in early stages of the illness.

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