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Associations of Executive Function With Concurrent and Prospective Reports of Obsessive-Compulsive Symptoms in Schizophrenia

Received September 10, 2007; revised October 15, 2007; accepted October 22, 2007. The authors are affiliated with the Roudebush VA Medical Center and the Indiana University School of Medicine, Dept of Psychiatry, in Indianapolis. Address correspondence to Paul Lysaker, Ph.D., Day Hospital 116H, 1481 West 10th St., Roudebush VA Medical Center, Indianapolis, IN 46202; plysaker{at}iupui.edu (e-mail).

Obsessive-compulsive symptoms (OCS) have been widely observed in schizophrenia and linked with concurrent deficits in executive function. Less clear though is whether OCS are prospectively linked with executive function independent of anxiety level. To explore these issues, OCS, state anxiety, and executive function were assessed among 41 participants with schizophrenia spectrum disorders. Measures of OCS and anxiety were then readministered 6 months later. Correlations revealed that a factor score derived from baseline measures of the inhibition domain of executive function was linked to both concurrent and future assessments of OCS even when state anxiety was controlled.

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