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Amount of HIV DNA in Peripheral Blood Mononuclear Cells is Proportional to the Severity of HIV-1-Associated Neurocognitive Disorders

Received June 14, 2007; revised October 13, 2007; accepted February 6, 2008. Drs. Shiramizu, Shikuma, and Valcour are affiliated with the Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu; Dr. Williams is affiliated with Kaiser Foundation Hospitals, Center for Health Research, Honolulu. Address correspondence to Bruce Shiramizu, 3675 Kilauea Ave., Young Building, 5th Floor, Honolulu, HI 96816; bshirami{at}hawaii.edu (e-mail).

Human immunodeficiency virus (HIV) DNA in peripheral blood mononuclear cells was previously associated with neuropsychological function. By including individuals encompassing the full range of HIV-1-associated neurocognitive disorders, this study reports results from subjects with normal cognition, minor cognitive motor disorder, and HIV-1-associated dementia. Individuals with normal cognition had relatively low HIV DNA levels compared to those with minor cognitive motor disorder and HIV-1-associated dementia. Neuropsychological deficits were significantly associated with entry HIV DNA in all domains. These findings demonstrate for the first time that the severity of HIV-1-associated neurocognitive disorders is proportional to the amount of circulating HIV DNA.

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