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Agrypnia Excitata: Current Concepts and Future Prospects in Management

Received January 21, 2008; revised April 26, 2008; accepted April 29, 2008. Dr. Hazin is affiliated with the Faculty of Arts and Sciences at Harvard University; Dr. Abuzetun is affiliated with the Division of Internal Medicine at Creighton University Medical Center; Dr. Giglio is affiliated with the Department of Neurosciences, Medical University of South Carolina; Dr. Khan is affiliated with the Neurodiagnostic and Sleep Center at Gulf Coast Medical Center in Wharton, Tex. Address correspondence to Faisal Khan, M.D., Neurodiagnostic and Sleep Center, Gulf Coast Medical Center, 10119 US 59 Road, Wharton, TX 77488-7224; fskhan786{at}gmail.com (e-mail).

Agrypnia excitata is an extremely rare, life-threatening syndrome characterized by autonomic activation, persistent insomnia, and generalized overactivity. Agrypnia excitata describes a triad of three separate conditions: delirium tremens, Morvan’s chorea, and familial fatal insomnia (FFI). Each of the aforementioned three conditions have sleep disturbances as a unifying theme and results in distinct neurophysiological findings. The following is an overview of agrypnia excitata with a particular emphasis placed upon each of the three individual conditions that constitute the syndrome with recommendations on appropriate management.

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