J Neuropsychiatry Clin Neurosci 21:152-159, Spring
doi: 10.1176/appi.neuropsych.21.2.152
© 2009 American Neuropsychiatric Association
Atrophy of Basal Ganglia Nuclei and Negative Symptoms in Temporal Lobe Epilepsy
Elizabeth K. Geary, Ph.D.,
Michael Seidenberg, Ph.D. and
Bruce Hermann, Ph.D.
Received January 9, 2008; revised June 13, 2008; accepted June 18, 2008. Drs. Geary and Seidenberg are affiliated with the Department of Psychology, Rosalind Franklin University of Medicine and Science, in North Chicago; Dr. Geary is also affiliated with the Department of Neurology and Rehabilitation at University of Illinois Chicago; Dr. Hermann is affiliated with the University of Wisconsin School of Medicine and Public Health. Address correspondence to Elizabeth Geary, Ph.D., Center for Stroke Research, University of Illinois Chicago, Department of Neurology, 912 South Wood St., Rm. 855N, M/C 796 Chicago 60612; ekgeary{at}uic.edu (e-mail).
Recent work has identified the presence of negative symptoms in a subset of temporal lobe epilepsy (TLE) patients. The authors hypothesized that negative symptoms in TLE are associated with disruption in the mesolimbic system. Basal ganglia and anterior cingulate region of interest volumes were compared between 22 TLE patients with negative symptoms, 22 TLE patients without negative symptoms, and 22 comparison subjects. The negative symptom group showed significantly reduced volumes in the putamen and globus pallidus. It appears that these structures within the broader mesolimbic system contribute to the phenomenon of negative symptoms in TLE.
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