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EEG Power Spectra Differentiate Positive and Negative Subgroups in Neuroleptic-Naive Schizophrenia Patients

Received May 18, 2007; revised March 15 and April 12, 2008; accepted April 21, 2008. Dr. John is affiliated with the Department of Psychiatry at NIMH and Neurosciences (NIMHANS), in Bangalore, India; Drs. Rangaswamy and Nagaraj are affiliated with Neurodynamics Laboratory, Department of Psychiatry at SUNY Downstate Medical Center in New York; Dr. Thennarasu is affiliated with the Department of Biostatistics at NIMHANS in Bangalore, India; Dr. Khanna is affiliated with The Psychiatric Clinic in New Delhi, India; Dr. Mukundan is formerly with the Department of Clinical Psychology at NIMHANS in Bangalore, India; Dr. Pradhan is affiliated with the Department of Psychopharmacology at NIMHANS in Bangalore, India. Address correspondence to John P. John, M.D., Assistant Professor of Psychiatry, NIMH and Neurosciences (NIMHANS), PB No 2900, Dharmaram P.O., Hosur Rd., Bangalore, Karnataka, 560 029, India; jpj{at}nimhans.kar.nic.in (e-mail).

Electroencephalogram spectral power was estimated at 30 scalp locations in 28 neuroleptic-naive, recent-onset schizophrenia (NRS) patients and 25 healthy comparison subjects in the resting eyes closed condition. Weighted relative power values in the various bandwidths were initially compared between NRS subjects and comparison subjects and subsequently between the positive symptom subgroup, negative symptom subgroup, and comparison subjects, to look for characteristic spectral power profiles of the homogeneous symptom subgroups. Significant differences were noted especially in alpha2, delta, and theta bands between NRS patients and healthy comparison subjects, while the positive symptom and negative symptom subgroups showed characteristic spectral power profiles in alpha1, alpha2, delta, and theta bands.

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