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Neural Correlates of Anxiety in Healthy Volunteers: A Voxel-Based Morphometry Study

Received November 9, 2007; revised March 19, 2008; accepted March 20, 2008. Dr. Spampinato is affiliated with the Radiology Department, Medical University of South Carolina; Drs. Wood and Grafman are affiliated with the Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH. Dr. de Simone is affiliated with Hospital Britanico de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina. Address correspondence to Jordan Grafman, Ph.D., Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bldg. 10, Room 7D43 MSC 1440, Bethesda, MD 20892-1440; grafmanj{at}ninds.nih.gov (e-mail).

Studies have shown that the amygdala, temporal, and prefrontal cortices play a key role in the expression of anxiety. The correlation between gray matter volume of these structures and behavioral anxiety measures was not previously investigated in healthy volunteers. The authors used voxel-based morphometry to assess the relationship between brain regional volume and anxiety. The authors found an inverse correlation between anxiety measures and cortical volume in regions of the limbic system and prefrontal cortex implicated in the pathogenesis of anxiety disorders. The authors suggest that volumetric variability of these regions may have a correlation with the development of an anxious personality trait.

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