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Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium

Received February 19, 2008; revised May 12 and August 28, 2008; accepted August 29, 2008. The authors are affiliated with the University of Amsterdam; Drs. van Munster, Moerland, Zwinderman, and Korevaar are affiliated with the Department of Clinical Epidemiology, Biostatistics and Bioinformatics; Drs. van Munster, de Rooij, and Levi are affiliated with the Department of Internal Medicine; Drs. van Breemen, Speijer, and Aerts are affiliated with the Department of Medical Biochemistry; Drs. Pfrommer and Hollmann are affiliated with the Department of Anesthesiology. Address correspondence to Barbara C. van Munster, M.D., Ph.D., Department of Internal Medicine, Subdivision Geriatrics F4, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands; b.c.vanmunster{at}amc.uva.nl (e-mail).

The aim of this study was to compare plasma and serum protein profiles in elderly acute hip fracture patients with and without delirium. The spectra from surface-enhanced laser desorption ionization (SELDI) using time-of-flight (TOF) mass spectrometry of 16 patients without and 16 patients with delirium (two groups of eight and eight) scored using the Confusion Assessment Method were compared. The most discriminating peak of 15.9 kDa in plasma in a testing group of eight patients with delirium to eight patients without delirium was confirmed in an independent validation group. Taking both groups together, three discriminating peaks of 7.97, 15.9, and 16.0 kDa were found in delirious patients. These peaks presumably correspond to hemoglobin-β, its doubly charged ion, and its glycosylated form.

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