J Neuropsychiatry Clin Neurosci 1991; 3:41-50
Copyright © 1991 by American Neuropsychiatric Association
Neuroendocrine responses to methylphenidate and d-amphetamine: applications to attention-deficit disorder
S Lurie and A O'Quinn
Duke University Medical Center, Durham, NC 27710, USA.
The authors reviewed the studies of the neuroendocrine secretion of growth
hormone, prolactin, and cortisol as they relate to attention- deficit
hyperactivity disorder (ADHD). Studies to date have focused on the hormonal
responses to the stimulants (amphetamines and methylphenidate) in children
and adults. The authors discuss the methodologic limitations of current
studies, the implications of this research for an understanding of the
pathophysiology of ADHD, as well as the mechanisms of action of the
stimulants and the side effect of stimulant-related growth suppression.
They also suggest directions for future research.
