J Neuropsychiatry Clin Neurosci 1991; 3:73-75
Copyright © 1991 by American Neuropsychiatric Association
Observations on the physostigmine syndrome in patients with Alzheimer's disease
E Wirkowski, I Prohovnik and WL Young
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
The authors present two patients with Alzheimer's disease who each received
a single intravenous dose of physostigmine. Subjective complaints and mood
changes were disproportional with objectively verified physiological side
effects. Such observations may contribute to an understanding of affective
disorders and should receive more attention in future studies of
cholinesterase inhibitors.
