J Neuropsychiatry Clin Neurosci 1991; 3:80-83
Copyright © 1991 by American Neuropsychiatric Association
Spontaneous remission of post-stroke depression and temporal changes in cortical S2-serotonin receptors
HS Mayberg, RM Parikh, PL Morris and RG Robinson
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
A patient with post-stroke depression following infarction of the left
basal ganglia is described. The patient's depression remitted during a
6-week double-blind treatment trial while receiving placebo medication.
Cortical S2-receptor binding that was measured using 11C-N methyl spiperone
and positron emission tomography (PET), increased in the left temporal
cortex by more than 25% during the treatment trial. The change in serotonin
receptor binding and its relationship to the improvement in mood observed
in this patient are consistent with previously published data demonstrating
a correlation between serotonin receptor binding in the left temporal
cortex and severity of symptoms of depression.
