The relationship of serum anticholinergic activity to mental status performance in an elderly nursing home population



	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted
	Citation Map



	Email this article to a Colleague
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Articles & Searches
	Download to citation manager



	Citing Articles via HighWire
	Citing Articles via Google Scholar



	Articles by Tollefson, G. D.
	Articles by Lancaster, S. P.
	Search for Related Content



	PubMed Citation
	Articles by Tollefson, G. D.
	Articles by Lancaster, S. P.

J Neuropsychiatry Clin Neurosci 1991; 3:314-319
Copyright © 1991 by American Neuropsychiatric Association

RANDOMIZED CONTROLLED TRIAL

The relationship of serum anticholinergic activity to mental status performance in an elderly nursing home population

GD Tollefson, J Montague-Clouse and SP Lancaster
Department of Psychiatry, St. Paul-Ramsey Medical Center, Minnesota 55101.

Adverse drug reactions among elderly patients pose a significant clinical problem. The authors used a serum radioreceptor assay [RRA] to quantify drug-induced muscarinic blockade in 34 randomly selected nursing home residents. A random intervention group and the nonintervention control subjects were then retested 4 weeks later. The reduction of serum antimuscarinic activity (as determined by RRA) did relate to changes on several measures of cognitive function. A calculated "antimuscarinic index" lost significance with the RRA following intervention and may have overestimated the impact of a dosage reduction.

This article has been cited by other articles:

M. L Ancelin, S. Artero, F. Portet, A.-M. Dupuy, J. Touchon, and K. Ritchie
Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study
BMJ, February 25, 2006; 332(7539): 455 - 459.
[Abstract] [Full Text] [PDF]

R. D. Jewart, J. Green, C.-j. Lu, J. Cellar, and L. E. Tune
Cognitive, Behavioral, and Physiological Changes in Alzheimer Disease Patients as a Function of Incontinence Medications
Am J Geriatr Psychiatry, April 1, 2005; 13(4): 324 - 328.
[Abstract] [Full Text] [PDF]

R. Basu, H. Dodge, G. P. Stoehr, and M. Ganguli
Sedative-Hypnotic Use of Diphenhydramine in a Rural, Older Adult, Community-Based Cohort: Effects on Cognition
Am J Geriatr Psychiatry, April 1, 2003; 11(2): 205 - 213.
[Abstract] [Full Text] [PDF]

B. H. Mulsant, B. G. Pollock, M. Kirshner, C. Shen, H. Dodge, and M. Ganguli
Serum Anticholinergic Activity in a Community-Based Sample of Older Adults: Relationship With Cognitive Performance
Arch Gen Psychiatry, February 1, 2003; 60(2): 198 - 203.
[Abstract] [Full Text] [PDF]

J. M. Ryan, S. W. Kidder, L. A. Daiello, and P. N. Tariot
Mental Health Services in Nursing Homes: Psychopharmacologic Interventions in Nursing Homes: What Do We Know and Where Should We Go?
Psychiatr Serv, November 1, 2002; 53(11): 1407 - 1413.
[Abstract] [Full Text] [PDF]

Get information about faster international access.