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J Neuropsychiatry Clin Neurosci 1991; 3:364-370
Copyright © 1991 by American Neuropsychiatric Association
Delusions in dementia syndromes: investigation of behavioral and neuropsychological correlates
FG Flynn, JL Cummings and J Gornbein
Neurobehavior Unit, West Los Angeles Veterans Affairs Medical Center, CA 90073.
A prospective cross-sectional investigation examining the relationship of
neuropsychological and behavioral changes to the occurrence of delusions in
dementia syndromes was conducted. Nineteen patients had Alzheimer's disease
(AD), and 14 had multi-infarct dementia (MID). Patients with and without
delusions were compared with regard to demographic characteristics,
neuropsychological and neurological features, and a variety of behavioral
disturbances. Delusional patients were more aggressive and exhibited more
severe activity disturbances than nondelusional patients. Delusional
patients were more severely cognitively impaired, but the
neuropsychological differences between the two groups were not outstanding.
These observations suggest that specific neuropsychological deficits are
not compelling predictors of delusions and that delusional patients are
more behaviorally disturbed than those without delusions. It is
hypothesized that delusions are independent noncognitive manifestations of
the neurobiology of AD and MID.
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