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J Neuropsychiatry Clin Neurosci 1992; 4:152-158
Copyright © 1992 by American Neuropsychiatric Association
Magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis
SJ Huber, RA Bornstein, KW Rammohan, JA Christy, DW Chakeres and RB McGhee
Department of Neurology, University of Kansas Medical Center, Kansas City 66103.
The authors examined whether specific neuropsychological abnormalities in
multiple sclerosis (MS) are associated with focal lesion areas detected by
MRI. Lesion area, regardless of distribution, correlated with performance
on the vast majority of neuropsychological procedures. No significant
difference appeared between groups with normal/mild and moderate overall
cognitive impairment on any of the MRI measures. However, patients with
severe cognitive impairment had greater lesion area, regardless of
location, and had significant atrophy of the corpus callosum compared with
the other two groups. These results suggest that severe atrophy of the
corpus callosum reflects global disease and provides a relatively focal
morphological marker of severe cognitive impairment in MS.
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