J Neuropsychiatry Clin Neurosci 1992; 4:159-167
Copyright © 1992 by American Neuropsychiatric Association
Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism
PR Martin, D Rio, B Adinoff, JL Johnson, JC Bisserbe, RR Rawlings, JW Rohrbaugh, JM Stapleton and MJ Eckardt
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
Localized cerebral utilization rates for glucose (CMRglu) were determined
in 10 detoxified patients with alcoholic organic mental disorders and in 7
age-equivalent normal volunteers using [18F]2-fluoro- 2-deoxyglucose
positron emission tomography. Although gray and white matter CMRglu were
not significantly different, normalized CMRglu was increased in the left
cerebellar and parietal cortical regions and decreased in the right
posterior white matter and anterior temporal regions of alcoholic patients,
and the pattern of regional CMRglu differed between the two groups. The
results suggest functional disruption of right-sided and frontal brain
regions and hyperactivity of cerebellar-cortical connections in alcoholic
chronic organic mental disorders.
