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J Neuropsychiatry Clin Neurosci 1992; 4:257-264
Copyright © 1992 by American Neuropsychiatric Association
Preliminary examination of the comorbidity of anxiety and depression in Parkinson's disease
R Henderson, R Kurlan, JM Kersun and P Como
University of Rochester NIMH Clinical Research Center for the Study of Psychopathology in the Elderly, NY.
Significant anxiety in combination with depression may represent a specific
depressive subtype in Parkinson's disease (PD). To ascertain the prevalence
of this symptom complex, we administered a self-report survey and
standardized psychological tests that measure anxiety and depression to 164
PD patients and 150 age-matched healthy spouse control subjects. The
reporting of depression in combination with panic/anxiety best
differentiated the two populations (38% vs. 8%). Depression and anxiety
were highly correlated in relationship to clinical features of PD. Our
findings suggest that clinically significant levels of depression and
anxiety may frequently coexist in PD. The specific neuropathology of PD may
predispose to this pattern of behavioral disturbance.
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