Cerebral metabolic dysfunction in AIDS: findings in a sample with and without dementia



	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted
	Citation Map



	Email this article to a Colleague
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Articles & Searches
	Download to citation manager



	Citing Articles via HighWire
	Citing Articles via Google Scholar



	Articles by van Gorp, W. G.
	Articles by Frederick, C. J.
	Search for Related Content



	PubMed Citation
	Articles by van Gorp, W. G.
	Articles by Frederick, C. J.

J Neuropsychiatry Clin Neurosci 1992; 4:280-287
Copyright © 1992 by American Neuropsychiatric Association

REGULAR ARTICLES

Cerebral metabolic dysfunction in AIDS: findings in a sample with and without dementia

WG van Gorp, MA Mandelkern, M Gee, CH Hinkin, CE Stern, DK Paz, W Dixon, G Evans, F Flynn and CJ Frederick
Neuropsychology Laboratory (B111), Department of Veterans Affairs Medical Center, West Los Angeles, CA 90073.

Positron-emission tomography was coupled with neurological and neuropsychological evaluation to study regional cerebral activity and neurologic status in two groups. Seventeen patients with full-blown AIDS and 14 seronegative control subjects were studied using [18F]2- fluoro-2-deoxy-D-glucose in a resting state. The AIDS group had relative regional hypermetabolism in the basal ganglia and thalamus; stepwise multiple-regression analyses revealed a significant relationship for the AIDS group between temporal lobe metabolism and severity of dementia on the AIDS Dementia Complex Rating Scale. These results suggest that the basal ganglia, thalamus, and temporal lobes are differentially affected in AIDS.

This article has been cited by other articles:

M. F. Georgiou, A. Gonenc, D. Waldrop-Valverde, R. A. Kuker, S. H. Ezuddin, G. N. Sfakianakis, and M. Kumar
Analysis of the Effects of Injecting Drug Use and HIV-1 Infection on 18F-FDG PET Brain Metabolism
J. Nucl. Med., December 1, 2008; 49(12): 1999 - 2005.
[Abstract] [Full Text] [PDF]

J. M. B. Castelo, M. G. Courtney, R. J. Melrose, and C. E. Stern
Putamen Hypertrophy in Nondemented Patients With Human Immunodeficiency Virus Infection and Cognitive Compromise
Arch Neurol, September 1, 2007; 64(9): 1275 - 1280.
[Abstract] [Full Text] [PDF]

C. G. Filippi, A. M. Ulu, E. Ryan, S. J. Ferrando, and W. van Gorp
Diffusion Tensor Imaging of Patients with HIV and Normal-appearing White Matter on MR Images of the Brain
AJNR Am. J. Neuroradiol., February 1, 2001; 22(2): 277 - 283.
[Abstract] [Full Text] [PDF]

H.-J. von Giesen, C. Antke, H. Hefter, F. Wenserski, R. J. Seitz, and G. Arendt
Potential Time Course of Human Immunodeficiency Virus Type 1-Associated Minor Motor Deficits: Electrophysiologic and Positron Emission Tomography Findings
Arch Neurol, November 1, 2000; 57(11): 1601 - 1607.
[Abstract] [Full Text] [PDF]

J. R. Berger and G. Arendt
HIV dementia: the role of the basal ganglia and dopaminergic systems
J Psychopharmacol, May 1, 2000; 14(3): 214 - 221.
[Abstract] [PDF]

J. R. Berger, A. Nath, R. N. Greenberg, A. H. Andersen, R. A. Greene, A. Bognar, and M. J. Avison
Cerebrovascular changes in the basal ganglia with HIV dementia
Neurology, February 22, 2000; 54(4): 921 - 926.
[Abstract] [Full Text] [PDF]

I. Grant, T. D. Marcotte, R. K. Heaton, and HNRC Group
Neurocognitive Complications of HIV Disease
Psychological Science, May 1, 1999; 10(3): 191 - 195.
[PDF]

M. B. Wiseman, J. A. Sanchez, C. Buechel, M. A. Mintun, O. L. Lopez, D. Milko, and J. T. Becker
Patterns of Relative Cerebral Blood Flow in Minor Cognitive Motor Disorder in Human Immunodeficiency Virus Infection
J Neuropsychiatry Clin Neurosci, May 1, 1999; 11(2): 222 - 233.
[Abstract] [Full Text]

Get information about faster international access.