J Neuropsychiatry Clin Neurosci 1992; 4:308-314
Copyright © 1992 by American Neuropsychiatric Association
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RANDOMIZED CONTROLLED TRIAL |
Differential effects of alprazolam and buspirone upon acquisition, retention, and retrieval processes in memory
JG Barbee, FW Black and AA Todorov
Department of Psychiatry, Louisiana State University School of Medicine, New Orleans 70112.
A group of 125 healthy young adults was given a memory battery 1 hour after
administration of alprazolam (0.5 and 1.0 mg), buspirone (5 and 10 mg), and
placebo under single-dose, double-blind conditions. On the wordlist recall
battery and a 24-hour retest, alprazolam appeared to impair acquisition and
retention in dosages of 1.0 mg; buspirone did not adversely affect test
performance at either dosage. On the basis of a 3-stage model of memory, a
neuroantomical/neurophysiological model is proposed to explain the
selective effects of the benzodiazepines on memory function.
