J Neuropsychiatry Clin Neurosci 1993; 5:316-321
Copyright © 1993 by American Neuropsychiatric Association
EEG coherence in men with AIDS: association with subcortical metabolic activity
TF Newton, AF Leuchter, DO Walter, WC Van Gorp, CE Stern, M Mandelkern and H Weiner
Department of Veterans Affairs Medical Center, West Los Angeles, CA 90073.
The authors studied the relationship between cerebral metabolism and brain
electrical activity in patients with acquired immunodeficiency syndrome
(AIDS), using positron-emission tomography and quantitative
electroencephalography. Electroencephalographic coherence in the 6-to 10-Hz
band correlated positively with thalamic metabolic activity. Coherence
adjusted for background activity correlated strongly and positively with
basal ganglia metabolic activity. Posterior interhemispheric coherence
showed the highest correlations with measures of metabolic activity. These
results suggest that changes in coherence may reflect AIDS-related
subcortical disease. The high correlations between the two different
measures of cerebral activity support the validity of
electroencephalographic coherence measures in studies of AIDS-related
neuropsychiatric dysfunction.
