J Neuropsychiatry Clin Neurosci 1993; 5:322-329
Copyright © 1993 by American Neuropsychiatric Association
Human brain fluoxetine concentrations
CN Karson, JE Newton, R Livingston, JB Jolly, TB Cooper, J Sprigg and RA Komoroski
Department of Psychiatry and Behavioral Sciences, University of Arkansas for Medical Sciences, Little Rock.
Data on 22 subjects treated with fluoxetine suggest that magnetic resonance
spectroscopy (MRS) of fluorine-19 can measure brain concentrations of
fluoxetine/norfluoxetine in vivo. Fluoxetine accumulates in the human brain
relative to plasma, with brain concentrations of fluoxetine/norfluoxetine
ranging up to 10.7 micrograms/ml. Brain concentrations may reach a plateau
between 6 and 8 months of treatment. The apparent concentration in brain
relative to plasma is 20:1, roughly parallel to brain antidepressant
concentration ratios in animal studies.
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