J Neuropsychiatry Clin Neurosci 1993; 5:415-418
Copyright © 1993 by American Neuropsychiatric Association
Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease: what is typical?
MF Weiner, WH Wighton-Benn, R Risser, D Svetlik, R Tintner, J Hom, RN Rosenberg and FJ Bonte
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070.
A study of 76 consecutive xenon-133 SPECT studies of regional cerebral
blood flow was undertaken to determine the frequency of various patterns of
blood flow in cases of clinically diagnosed probable and possible
Alzheimer's disease. The reference tomographic section was a slice 6 cm
above and parallel to the canthomeatal line. With the use of this
technique, the "classic" finding of bilateral temporoparietal (TP) flow
reductions as the sole abnormality occurred in only 28% of cases. Bilateral
TP reductions accompanied by bilateral or unilateral frontal flow
reductions were nearly as common (24%), and other patterns accounted for
the other 48% of cases.
