The Journal of Neuropsychiatry and Clinical Neurosciences
Journal Home Search Current Issue Past Issues Subscribe All APPI Journals Help Contact Us
 
Quicksearch
Advanced Search
Or Search All APPI Journals
This Article
* Full Text (PDF)
* Alert me when this article is cited
* Alert me if a correction is posted
* Citation Map
Services
* Email this article to a Colleague
* Similar articles in this journal
* Similar articles in PubMed
* Alert me to new issues of the journal
* Add to My Articles & Searches
* Download to citation manager
* reprints & permissions
Citing Articles
* Citing Articles via HighWire
* Citing Articles via Google Scholar
Google Scholar
* Articles by Mayberg, H. S.
* Search for Related Content
PubMed
* PubMed Citation
* Articles by Mayberg, H. S.

J Neuropsychiatry Clin Neurosci 1994; 6:428-442
Copyright © 1994 by American Neuropsychiatric Association

REGULAR ARTICLES

Frontal lobe dysfunction in secondary depression

HS Mayberg
Department of Medicine (Neurology), University of Texas Health Science Center at San Antonio 78284-6240.

Depression is common in patients with neurological disease, particularly with diseases involving the basal ganglia. Although the mechanisms of mood disorders in these patients are poorly understood, selective neural pathways affected directly and indirectly by basal ganglia injury provide a strategy for examining these patients with functional imaging techniques. Studies of regional cerebral glucose metabolism by use of positron-emission tomography are reviewed. These studies demonstrate bilateral hypometabolism of orbital-inferior prefrontal cortex and anterior temporal cortex in depressed subjects, independent of disease etiology. This pattern is similar to that seen in patients with primary unipolar depression. These findings suggest that disruption of paralimbic pathways linking frontal cortex, temporal cortex, and striatum may contribute to both primary depression and depression associated with basal ganglia disease. The findings support the evolving concept of a neuroanatomical locus for mood regulation.


This article has been cited by other articles:


Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
M. F. Dulay, A. M. Strutt, H. S. Levin, J. Jankovic, E. C. Lai, R. G. Grossman, and M. K. York
Depressed Mood and Memory Impairment Before and After Unilateral Posteroventral Pallidotomy in Parkinson's Disease
J Neuropsychiatry Clin Neurosci, August 1, 2008; 20(3): 357 - 363.
[Abstract] [Full Text] [PDF]

Home page
 FocusHome page
H. S. Mayberg, A. M. Lozano, V. Voon, H. E. McNeely, D. Seminowicz, C. Hamani, J. M. Schwalb, and S. H. Kennedy
Deep Brain Stimulation for Treatment-Resistant Depression
Focus, January 1, 2008; 6(1): 143 - 154.
[Abstract] [Full Text] [PDF]

Home page
 Acad. PsychiatryHome page
J. Posner, J. Stewart, and R. Rieder
Neurobiological Formulations: Integrating Clinical and Biological Psychiatry
Acad Psychiatry, December 1, 2007; 31(6): 479 - 484.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
A. Y. Joe, T. Tielmann, J. Bucerius, M. J. Reinhardt, H. Palmedo, W. Maier, H.-J. Biersack, and A. Zobel
Response-Dependent Differences in Regional Cerebral Blood Flow Changes with Citalopram in Treatment of Major Depression
J. Nucl. Med., August 1, 2006; 47(8): 1319 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
H. J. Rosen, S. C. Allison, G. F. Schauer, M. L. Gorno-Tempini, M. W. Weiner, and B. L. Miller
Neuroanatomical correlates of behavioural disorders in dementia
Brain, November 1, 2005; 128(11): 2612 - 2625.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. D. Bremner, N. Fani, A. Ashraf, J. R. Votaw, M. E. Brummer, T. Cummins, V. Vaccarino, M. M. Goodman, L. Reed, S. Siddiq, et al.
Functional Brain Imaging Alterations in Acne Patients Treated With Isotretinoin
Am J Psychiatry, May 1, 2005; 162(5): 983 - 991.
[Abstract] [Full Text] [PDF]

Home page
 AJGPHome page
H. E. Cannon-Spoor, J. A. Levy, G. S. Zubenko, W. W. Zubenko, R. M. Cohen, N. Mirza, K. Putnam, and T. Sunderland
Effects of Previous Major Depressive Illness on Cognition in Alzheimer Disease Patients
Am J Geriatr Psychiatry, April 1, 2005; 13(4): 312 - 318.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
D. Weintraub, A. B. Newberg, M. S. Cary, A. D. Siderowf, P. J. Moberg, G. Kleiner-Fisman, J. E. Duda, M. B. Stern, D. Mozley, and I. R. Katz
Striatal Dopamine Transporter Imaging Correlates with Anxiety and Depression Symptoms in Parkinson's Disease
J. Nucl. Med., February 1, 2005; 46(2): 227 - 232.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. D. Bremner, M. Vythilingam, E. Vermetten, V. Vaccarino, and D. S. Charney
Deficits in Hippocampal and Anterior Cingulate Functioning During Verbal Declarative Memory Encoding in Midlife Major Depression
Am J Psychiatry, April 1, 2004; 161(4): 637 - 645.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Feinstein, P. Roy, N. Lobaugh, K. Feinstein, P. O'Connor, and S. Black
Structural brain abnormalities in multiple sclerosis patients with major depression
Neurology, February 24, 2004; 62(4): 586 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
R. E. Jorge, R. G. Robinson, D. Moser, A. Tateno, B. Crespo-Facorro, and S. Arndt
Major Depression Following Traumatic Brain Injury
Arch Gen Psychiatry, January 1, 2004; 61(1): 42 - 50.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
P. Davanzo, K. Yue, M. A. Thomas, T. Belin, J. Mintz, T.N. Venkatraman, E. Santoro, S. Barnett, and J. McCracken
Proton Magnetic Resonance Spectroscopy of Bipolar Disorder Versus Intermittent Explosive Disorder in Children and Adolescents
Am J Psychiatry, August 1, 2003; 160(8): 1442 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. D. Bremner, M. Vythilingam, C. K. Ng, E. Vermetten, A. Nazeer, D. A. Oren, R. M. Berman, and D. S. Charney
Regional Brain Metabolic Correlates of {alpha}-Methylparatyrosine-Induced Depressive Symptoms: Implications for the Neural Circuitry of Depression
JAMA, June 18, 2003; 289(23): 3125 - 3134.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
H. S Mayberg
Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment
Br. Med. Bull., March 1, 2003; 65(1): 193 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
M. Liotti, H. S. Mayberg, S. McGinnis, S. L. Brannan, and P. Jerabek
Unmasking Disease-Specific Cerebral Blood Flow Abnormalities: Mood Challenge in Patients With Remitted Unipolar Depression
Am J Psychiatry, November 1, 2002; 159(11): 1830 - 1840.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
H. S. Mayberg, J. A. Silva, S. K. Brannan, J. L. Tekell, R. K. Mahurin, S. McGinnis, and P. A. Jerabek
The Functional Neuroanatomy of the Placebo Effect
Am J Psychiatry, May 1, 2002; 159(5): 728 - 737.
[Abstract] [Full Text] [PDF]

Home page
 AJGPHome page
G. S. Alexopoulos, D. N. Kiosses, S. Klimstra, B. Kalayam, and M. L. Bruce
Clinical Presentation of the ""Depression-Executive Dysfunction Syndrome"" of Late Life
Am J Geriatr Psychiatry, February 1, 2002; 10(1): 98 - 106.
[Abstract] [Full Text] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
S. Norman, A. I. Troster, J. A. Fields, and R. Brooks
Effects of Depression and Parkinson's Disease on Cognitive Functioning
J Neuropsychiatry Clin Neurosci, February 1, 2002; 14(1): 31 - 36.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
S. H. Kennedy, K. R. Evans, S. Kruger, H. S. Mayberg, J. H. Meyer, S. McCann, A. I. Arifuzzman, S. Houle, and F. J. Vaccarino
Changes in Regional Brain Glucose Metabolism Measured With Positron Emission Tomography After Paroxetine Treatment of Major Depression
Am J Psychiatry, June 1, 2001; 158(6): 899 - 905.
[Abstract] [Full Text] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
J. R. Fann, J. M. Uomoto, and W. J. Katon
Sertraline in the Treatment of Major Depression Following Mild Traumatic Brain Injury
J Neuropsychiatry Clin Neurosci, May 1, 2000; 12(2): 226 - 232.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
G. S. Alexopoulos, B. S. Meyers, R. C. Young, B. Kalayam, T. Kakuma, M. Gabrielle, J. A. Sirey, and J. Hull
Executive Dysfunction and Long-term Outcomes of Geriatric Depression
Arch Gen Psychiatry, March 1, 2000; 57(3): 285 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
B. Kalayam and G. S. Alexopoulos
Prefrontal Dysfunction and Treatment Response in Geriatric Depression
Arch Gen Psychiatry, August 1, 1999; 56(8): 713 - 718.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
H. S. Mayberg, M. Liotti, S. K. Brannan, S. McGinnis, R. K. Mahurin, P. A. Jerabek, J. A. Silva, J. L. Tekell, C. C. Martin, J. L. Lancaster, et al.
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Am J Psychiatry, May 1, 1999; 156(5): 675 - 682.
[Abstract] [Full Text]

Home page
 Arch Gen PsychiatryHome page
K. Yaffe, T. Blackwell, R. Gore, L. Sands, V. Reus, and W. S. Browner
Depressive Symptoms and Cognitive Decline in Nondemented Elderly Women: A Prospective Study
Arch Gen Psychiatry, May 1, 1999; 56(5): 425 - 430.
[Abstract] [Full Text] [PDF]


Get information about faster international access.

Privacy Policy

Copyright © 1994 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us

American Psychiatric Publishing, Inc. American Neuropsychiatric Association
1000 Wilson Boulevard, Suite 1825, Arlington, VA 22209-3901 * 800-368-5777 * appi at psych.org