|
| | |
|
J Neuropsychiatry Clin Neurosci 1995; 7:23-30
Copyright © 1995 by American Neuropsychiatric Association
Apathy: a treatable syndrome
RS Marin, BS Fogel, J Hawkins, J Duffy and B Krupp
Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA.
Apathy occurs frequently in neuropsychiatric disorders both as a symptom of
other syndromes and as a syndrome per se. Histories are presented of
patients with a syndrome of apathy who showed clinically significant,
sustained benefit from pharmacological treatment. Etiologies included
non-Alzheimer's frontal lobe dementia, cerebral infarction, intracranial
hemorrhage, alcoholism, and traumatic brain injury. Agents included
amantadine, amphetamine, bromocriptine, bupropion, methylphenidate, and
selegiline. These histories support the suggestion that apathy is a
discriminable dimension of behavior having its own pathophysiology and
implications for psychiatric care. They raise the possibility of treatment
for many patients previously thought untreatable. Studying the treatment of
apathy may contribute to the clinical care and scientific understanding of
neuropsychiatric disorders throughout the life span.
This article has been cited by other articles:
|
|
|
|
 
K. Demyttenaere and L. Jaspers
Review: Bupropion and SSRI-induced side effects
J Psychopharmacol,
September 1, 2008;
22(7):
792 - 804.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Nutt, K. Demyttenaere, Z. Janka, T. Aarre, M. Bourin, P. L. Canonico, J. L. Carrasco, and S. Stahl
The other face of depression, reduced positive affect: the role of catecholamines in causation and cure
J Psychopharmacol,
July 1, 2007;
21(5):
461 - 471.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. U. Onyike, J.-M. E. Sheppard, J. T. Tschanz, M. C. Norton, R. C. Green, M. Steinberg, K. A. Welsh-Bohmer, J. C. Breitner, and C. G. Lyketsos
Epidemiology of Apathy in Older Adults: The Cache County Study
Am J Geriatr Psychiatry,
May 1, 2007;
15(5):
365 - 375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Lavretsky, M. Ballmaier, D. Pham, A. Toga, and A. Kumar
Neuroanatomical Characteristics of Geriatric Apathy and Depression: A Magnetic Resonance Imaging Study
Am J Geriatr Psychiatry,
May 1, 2007;
15(5):
386 - 394.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R. Padala, W. J. Burke, S. C. Bhatia, and F. Petty
Treatment of Apathy With Methylphenidate
J Neuropsychiatry Clin Neurosci,
February 1, 2007;
19(1):
81 - 83.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R Padala, W. J Burke, and S. C Bhatia
Modafinil Therapy for Apathy in an Elderly Patient
Ann. Pharmacother.,
February 1, 2007;
41(2):
346 - 349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Huey, K. T. Putnam, and J. Grafman
A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia
Neurology,
January 10, 2006;
66(1):
17 - 22.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Landes, S. D. Sperry, and M. E. Strauss
Prevalence of Apathy, Dysphoria, and Depression in Relation to Dementia Severity in Alzheimer's Disease
J Neuropsychiatry Clin Neurosci,
August 1, 2005;
17(3):
342 - 349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. D. Volkow, G.-J. Wang, J. S. Fowler, F. Telang, L. Maynard, J. Logan, S. J. Gatley, N. Pappas, C. Wong, P. Vaska, et al.
Evidence That Methylphenidate Enhances the Saliency of a Mathematical Task by Increasing Dopamine in the Human Brain
Am J Psychiatry,
July 1, 2004;
161(7):
1173 - 1180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Corcoran, M. L. Wong, and V. O'Keane
Bupropion in the management of apathy
J Psychopharmacol,
March 1, 2004;
18(1):
133 - 135.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. M. Zawacki, J. Grace, R. Paul, D. J. Moser, B. R. Ott, N. Gordon, and R. A. Cohen
Behavioral Problems as Predictors of Functional Abilities of Vascular Dementia Patients
J Neuropsychiatry Clin Neurosci,
August 1, 2002;
14(3):
296 - 302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Lavretsky, I. M. Lesser, M. Wohl, B. L. Miller, and C. M. Mehringer
Clinical and Neuroradiologic Features Associated With Chronicity in Late-Life Depression
Am J Geriatr Psychiatry,
November 1, 1999;
7(4):
309 - 316.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. S. L. Fones and G. S. Alexopoulos
Distinguishing Apathy Syndromes From Vascular Depression
Arch Gen Psychiatry,
September 1, 1998;
55(9):
844 - 845.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Levy, J. L. Cummings, L. A. Fairbanks, D. Masterman, B. L. Miller, A. H. Craig, J. S. Paulsen, and I. Litvan
Apathy Is Not Depression
J Neuropsychiatry Clin Neurosci,
August 1, 1998;
10(3):
314 - 319.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. A. Castellon, C. H. Hinkin, S. Wood, and K. T. Yarema
Apathy, Depression, and Cognitive Performance in HIV-1 Infection
J Neuropsychiatry Clin Neurosci,
August 1, 1998;
10(3):
320 - 329.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. J. Knesper
The Depressions of Alzheimer's Disease: Sorting, Pharmacotherapy, and Clinical Advice
J Geriatr Psychiatry Neurol,
October 1, 1995;
8(1):
S40 - S51.
[Abstract]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1995
American Neuropsychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
