J Neuropsychiatry Clin Neurosci 1995; 7:180-187
Copyright © 1995 by American Neuropsychiatric Association
Cerebral metabolic change in patients with AIDS: report of a six-month follow-up using positron-emission tomography
CH Hinkin, WG van Gorp, MA Mandelkern, M Gee, P Satz, S Holston, TD Marcotte, G Evans, DH Paz and JR Ropchan
UCLA School of Medicine 90024-1759, USA.
The authors examined change in cerebral metabolic function over time by
using PET in HIV-infected individuals diagnosed with AIDS. Ten subjects
with AIDS received [18F]2-fluoro-2-deoxy-D-glucose PET scans and completed
a comprehensive neuropsychological battery. The scan and test battery were
repeated after 6 months. Over time, the subjects showed increased relative
basal ganglia metabolism as well as increased parietal lobe metabolism.
There were no statistically significant changes in neuropsychological
performance. These results suggest that PET may be more sensitive than
traditional neuropsychological evaluation to subtle central nervous system
changes in AIDS.
