Clozapine for acute and maintenance treatment of psychosis in Parkinson's disease



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	Articles by Chacko, R. C.
	Articles by Cardoso, F.

J Neuropsychiatry Clin Neurosci 1995; 7:471-475
Copyright © 1995 by American Neuropsychiatric Association

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Clozapine for acute and maintenance treatment of psychosis in Parkinson's disease

RC Chacko, RA Hurley, RG Harper, J Jankovic and F Cardoso
Department of Psychiatry/Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.

In a prospective, open-label study, 12 patients manifesting psychosis associated with Parkinson's disease were treated with clozapine. Cognitive functioning and type of psychotic symptoms were measured prior to treatment, and changes in psychiatric and behavioral symptoms were studied by using the Behave-AD Scale. Significant resolution in psychotic symptoms was found and improvement in global behavioral status observed in all cases, with 10 patients maintaining improvement at follow-up. Careful initiation and titration of the drug resulted in few side effects, and dementia was not found to be a contraindication to such treatment.

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