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J Neuropsychiatry Clin Neurosci 1995; 7:502-504
Copyright © 1995 by American Neuropsychiatric Association

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Successful methylphenidate treatment of apathy after subcortical infarcts

MD Watanabe, EM Martin, OA DeLeon, M Gaviria, DG Pavel and DW Trepashko
Department of Pharmacy Practice, University of Illinois-Chicago 60612, USA.

A patient with prominent apathy secondary to multiple subcortical infarcts was treated successfully with methylphenidate. SPECT and reaction time testing showed selective improvement of frontal system function, consistent with a recent model of frontal-subcortical circuits and behavior.




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