|
| | |
|
J Neuropsychiatry Clin Neurosci 1996; 8:41-46
Copyright © 1996 by American Neuropsychiatric Association
Apathy and loss of insight in Alzheimer's disease: a SPECT imaging study
BR Ott, RB Noto and BS Fogel
Roger Williams Medical Center Division of Neurology, Providence, RI 02908, US
Apathy and loss of insight as correlates of behavior in Alzheimer's disease
(AD) were studied in 40 patients by using clinical scales and cerebral
blood flow measurements from SPECT imaging. Apathy was significantly
correlated with decreased right temporoparietal perfusion and problem
behaviors. Loss of insight was significantly correlated with decreased
right temporo-occipital perfusion and impairment in daily functioning.
Dementia severity as measured by the Mini-Mental State Examination (MMSE)
was a poor predictor of behavioral problems or daily functioning. These
data suggest that global measures of cognitive ability, which are weighted
toward measuring left hemisphere function, are less important as indicators
of management problems in AD than are measures of right hemisphere function
such as motivation and insight.
This article has been cited by other articles:
|
|
|
|
 
M. D. Orfei, R. G. Robinson, P. Bria, C. Caltagirone, and G. Spalletta
Unawareness of Illness in Neuropsychiatric Disorders: Phenomenological Certainty versus Etiopathogenic Vagueness
Neuroscientist,
April 1, 2008;
14(2):
203 - 222.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. E. Ready and B. R. Ott
Integrating Patient and Informant Reports on the Cornell-Brown Quality-of-Life Scale
American Journal of Alzheimer's Disease and Other Dementias,
January 1, 2008;
22(6):
528 - 534.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. A. Marshall, L. Monserratt, D. Harwood, M. Mandelkern, J. L. Cummings, and D. L. Sultzer
Positron Emission Tomography Metabolic Correlates of Apathy in Alzheimer Disease
Arch Neurol,
July 1, 2007;
64(7):
1015 - 1020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Robertsson, M. Nordstrom, and H. Wijk
Investigating poor insight in Alzheimer's disease: A survey of research approaches
Dementia,
February 1, 2007;
6(1):
45 - 61.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. M. McMurtray, A. K. Chen, J. S. Shapira, T. W. Chow, F. Mishkin, B. L. Miller, and M. F. Mendez
Variations in regional SPECT hypoperfusion and clinical features in frontotemporal dementia
Neurology,
February 28, 2006;
66(4):
517 - 522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Harwood, D. L. Sultzer, D. Feil, L. Monserratt, E. Freedman, and M. A. Mandelkern
Frontal Lobe Hypometabolism and Impaired Insight in Alzheimer Disease
Am J Geriatr Psychiatry,
November 1, 2005;
13(11):
934 - 941.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Rosen, S. C. Allison, G. F. Schauer, M. L. Gorno-Tempini, M. W. Weiner, and B. L. Miller
Neuroanatomical correlates of behavioural disorders in dementia
Brain,
November 1, 2005;
128(11):
2612 - 2625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Landes, S. D. Sperry, and M. E. Strauss
Prevalence of Apathy, Dysphoria, and Depression in Relation to Dementia Severity in Alzheimer's Disease
J Neuropsychiatry Clin Neurosci,
August 1, 2005;
17(3):
342 - 349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. Mendez and J. S. Shapira
Loss of Insight and Functional Neuroimaging in Frontotemporal Dementia
J Neuropsychiatry Clin Neurosci,
August 1, 2005;
17(3):
413 - 416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. van Reekum, D. T. Stuss, and L. Ostrander
Apathy: Why Care?
J Neuropsychiatry Clin Neurosci,
February 1, 2005;
17(1):
7 - 19.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G A Marshall, D I Kaufer, O L Lopez, G R Rao, R L Hamilton, and S T DeKosky
Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry,
October 1, 2004;
75(10):
1396 - 1400.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Cahn-Weiner, R. E. Ready, and P. F. Malloy
Neuropsychological Predictors of Everyday Memory and Everyday Functioning in Patients with Mild Alzheimer's Disease
J Geriatr Psychiatry Neurol,
June 1, 2003;
16(2):
84 - 89.
[Abstract]
[PDF]
|
|
|
|
|
|
|
O. L. Lopez, S. Zivkovic, G. Smith, J. T. Becker, C. C. Meltzer, and S. T. DeKosky
Psychiatric Symptoms Associated With Cortical-Subcortical Dysfunction in Alzheimer's Disease
J Neuropsychiatry Clin Neurosci,
February 1, 2001;
13(1):
56 - 60.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
W. J. Burke, W. H. Roccaforte, S. P. Wengel, D. McArthur-Miller, D. G. Folks, and J. F. Potter
Disagreement in the Reporting of Depressive Symptoms Between Patients With Dementia of the Alzheimer Type and their Collateral Sources
Am J Geriatr Psychiatry,
November 1, 1998;
6(4):
308 - 319.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. L. Levy, J. L. Cummings, L. A. Fairbanks, D. Masterman, B. L. Miller, A. H. Craig, J. S. Paulsen, and I. Litvan
Apathy Is Not Depression
J Neuropsychiatry Clin Neurosci,
August 1, 1998;
10(3):
314 - 319.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. A. Castellon, C. H. Hinkin, S. Wood, and K. T. Yarema
Apathy, Depression, and Cognitive Performance in HIV-1 Infection
J Neuropsychiatry Clin Neurosci,
August 1, 1998;
10(3):
320 - 329.
[Abstract]
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1996
American Neuropsychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
