J Neuropsychiatry Clin Neurosci 1996; 8:92-96
Copyright © 1996 by American Neuropsychiatric Association
Clinical utility of clozapine in 16 patients with neurological disease
JD Duffy and R Kant
Department of Psychiatry, Medical College of Pennsylvania, Pittsburgh, PA 15212, USA.
Patients who develop psychosis or agitated behavior secondary to
neurological disorders present a therapeutic dilemma. The authors review
clinical efficacy and side effect profiles of clozapine in a cohort of 16
patients with various neurobehavioral disorders. One-third showed a marked
decrease in symptoms while on clozapine. However, one- quarter developed an
acute confusional state; of these, all had diffuse slowing on their
baseline EEG prior to starting the drug.
