J Neuropsychiatry Clin Neurosci 1996; 8:194-201
Copyright © 1996 by American Neuropsychiatric Association
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RANDOMIZED CONTROLLED TRIAL |
Conditioning of cyclophosphamide-induced leukopenia in humans
DW Giang, AD Goodman, RB Schiffer, DH Mattson, M Petrie, N Cohen and R Ader
Department of Neurology, Center for Psychoneuroimmunology Research, University of Rochester Medical Center, Rochester, NY 14642, USA.
This study evaluated whether decrements in peripheral leukocyte counts
induced by cyclophosphamide can be conditioned in humans. Ten subjects
being treated for multiple sclerosis received four intravenous treatments
with cyclophosphamide (unconditioned stimulus) paired with a conditioned
stimulus. Subjects received conditioned stimulus plus 10 mg of
cyclophosphamide during one of the next two treatments in a double- blind
manner. Eight of 10 subjects (P = 0.044) displayed decreased peripheral
leukocyte counts following conditioned stimulus. This change may have
resulted from classical conditioning processes.
