Gender differences in cortical glucose metabolism in Alzheimer's disease and normal aging



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J Neuropsychiatry Clin Neurosci 1996; 8:211-214
Copyright © 1996 by American Neuropsychiatric Association

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Gender differences in cortical glucose metabolism in Alzheimer's disease and normal aging

BV Siegel Jr, L Shihabuddin, MS Buchsbaum, A Starr, RJ Haier and DC Valladares Neto
Department of Psychiatry, University of California, Irvine, USA.

Male Alzheimer's disease patients, studied with 18-fluoro-2- deoxyglucose positron emission tomography while performing a verbal memory test, showed a right-greater-than-left asymmetry of cortical metabolism that tended to be greater than that in healthy, age-matched control subjects. This asymmetry was absent in female patients, preliminarily suggesting a propensity for left hemispheric involvement in the Alzheimer's disease process in males.

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