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J Neuropsychiatry Clin Neurosci 1996; 8:249-261
Copyright © 1996 by American Neuropsychiatric Association


REGULAR ARTICLES

Anatomy and function of the orbital frontal cortex, II: Function and relevance to obsessive-compulsive disorder

DH Zald and SW Kim
Department of Psychology, University of Minnesota, Minneapolis 55455, USA.

The authors review neurophysiological, neurobehavioral, and neuropsychological investigations of the orbital frontal cortex (OFC) in human and non-human primates. The article critically examines the role of the OFC in 1) recognition of reinforcers; 2) stimulus- reinforcer learning; 3) modulation of responses based on changes in reinforcement contingencies; 4) emotions, social behavior, and autonomic regulation; 5) mnemonic functions; and 6) rule learning. Examining these functional areas with reference to the OFC's anatomical and neurophysiological properties, the authors suggest ways in which the OFC might contribute to obsessive-compulsive disorder.


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