Clozapine for the treatment of psychosis in Parkinson's disease: chart review of 49 patients



	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted



	Email this article to a Colleague
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Articles & Searches
	Download to citation manager



	Citing Articles via HighWire
	Citing Articles via Google Scholar



	Articles by Wagner, M. L.
	Articles by Sage, J. I.
	Search for Related Content



	PubMed Citation
	Articles by Wagner, M. L.
	Articles by Sage, J. I.

J Neuropsychiatry Clin Neurosci 1996; 8:276-280
Copyright © 1996 by American Neuropsychiatric Association

REGULAR ARTICLES

Clozapine for the treatment of psychosis in Parkinson's disease: chart review of 49 patients

ML Wagner, JL Defilippi, MA Menza and JI Sage
Department of Pharmacy Practice, Rutgers, State University of New Jersey, Piscataway 08855-0789, USA.

The records of 49 patients with Parkinson's disease and psychosis who were treated with clozapine for up to 18 months were reviewed. Average starting dose of clozapine was 16 mg. Average maximum dose was 39 mg. The psychotic symptoms improved in 76% of the patients at 3 months, and response to clozapine within the first year ranged from 71% to 80%. This response allowed a maximization of levodopa dose. Improvements in scores on the Unified Parkinson's Disease Rating Scale and tremor subscale were seen in some patients but were not statistically significant. This study, the largest of its kind to date, suggests that clozapine is well tolerated and effective in treating psychosis in patients with Parkinson's disease.

This article has been cited by other articles:

U. Lertxundi, J. Peral, O. Mora, S. Domingo-Echaburu, M. J. Martinez-Bengoechea, and J. C. Garcia-Monco
Antidopaminergic therapy for managing comorbidities in patients with Parkinson's disease
Am. J. Health Syst. Pharm., March 1, 2008; 65(5): 414 - 419.
[Abstract] [Full Text] [PDF]

P Pollak, F Tison, O Rascol, A Destee, J J Pere, J M Senard, F Durif, and I Bourdeix
Clozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up
J. Neurol. Neurosurg. Psychiatry, May 1, 2004; 75(5): 689 - 695.
[Abstract] [Full Text] [PDF]

The Parkinson Study Group
Low-Dose Clozapine for the Treatment of Drug-Induced Psychosis in Parkinson's Disease
N. Engl. J. Med., March 11, 1999; 340(10): 757 - 763.
[Abstract] [Full Text] [PDF]

Get information about faster international access.