J Neuropsychiatry Clin Neurosci 1996; 8:335-337
Copyright © 1996 by American Neuropsychiatric Association
Apo-E genotype and verbal deficits in Alzheimer's disease
DX Rasmusson, G Dal Forno, J Brandt, AC Warren, J Troncoso and C Lyketsos
Department of Psychiatry/Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. xeno@mvx.grc.nia.nih.gov
Apo-E genotype was not significantly related to cognitive performance in
157 Alzheimer's disease patients. However, patients homozygous for the
epsilon 4 allele appeared most impaired on global cognition but least
impaired on language measures. Further study with larger samples may reveal
that Apo-E genotype accounts for some of the variability in cognitive
deficits observed in Alzheimer's disease.