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J Neuropsychiatry Clin Neurosci 1997; 9:64-67
Copyright © 1997 by American Neuropsychiatric Association
Depression, delusions, and hallucinations in Alzheimer's disease: no relationship to apolipoprotein E genotype
CG Lyketsos, L Baker, A Warren, C Steele, J Brandt, M Steinberg, S Kopunek and A Baker
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
The apolipoprotein E (APOE) locus on chromosome 19 has been shown to modify
risk, and age at onset, of Alzheimer's disease (AD). The authors
hypothesized that the phenotypic expression of different psychiatric
symptoms in patients with AD would be associated with variability in APOE
locus. Neuropsychiatric and genetic testing of 120 probable AD patients
revealed 28% had major depression, 17% had minor depression, 30% had
delusions, and 14% had hallucinations; 69% were carriers of at least one
APOE E4 allele (14% homozygous E4/E4, 49% heterozygous E3/E4, 6%
heterozygous E2/E4, 29% homozygous E3/E3, 2% heterozygous E2/E3).
Prevalence of the various psychiatric disturbances did not differ
significantly in AD patients with different APOE genotypes. Apolipoprotein
E does not appear to modify the risk of developing AD- associated
psychiatric symptomatology.
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