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J Neuropsychiatry Clin Neurosci 1997; 9:251-258
Copyright © 1997 by American Neuropsychiatric Association
Lack of clinically significant gross structural abnormalities in MRIs of older patients with schizophrenia and related psychoses
LL Symonds, JM Olichney, TL Jernigan, J Corey-Bloom, JF Healy and DV Jeste
Departments of Psychiatry and Neurosciences, University of California, San Diego, USA.
The authors examined the reports of MRI brain studies of 69 patients with
DSM-III-R-diagnosed psychotic disorders (30 early-onset and 24 late-onset
schizophrenia patients and 15 with other psychoses) and 41 normal
comparison subjects. Participants' ages ranged from 45 to 87 years. A
qualitative rating scheme determined type and severity of clinically
detectable abnormalities, including volume loss, infarcts, lacunae, and
white matter hyperintensities. In this clinically well- characterized
sample, the vast majority of the MRIs were within normal limits. There were
no significant differences between psychosis patients and normal comparison
subjects or between early-onset and late- onset schizophrenia patients in
frequency, type, or severity of gross structural abnormalities. The results
indicate that late-onset schizophrenia and related disorders can exist
without clinically significant gross structural abnormalities in the brain.
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