The accumbens: beyond the core-shell dichotomy



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J Neuropsychiatry Clin Neurosci 1997; 9:354-381
Copyright © 1997 by American Neuropsychiatric Association

REGULAR ARTICLES

The accumbens: beyond the core-shell dichotomy

L Heimer, GF Alheid, JS de Olmos, HJ Groenewegen, SN Haber, RE Harlan and DS Zahm
Department of Otolaryngology-Head and Neck Surgery, University of Virginia, Charlottesville 22908, USA.

This article highlights recent discoveries related to the accumbens and closely associated structures, with special reference to their importance in neuropsychiatry. The development of "striatal patches" in the accumbens is reviewed in a series of pictures. Neuronal ensembles are discussed as potentially important functional-anatomical units. Attention is also drawn to recent discoveries related to the neuronal circuits that the primate accumbens establishes with the mesencephalic dopamine system. On the basis of histological and neurochemical differences, the accumbens has been divided into core and shell compartments. In the context of this article, the shell, which is an especially diversified part of the accumbens, is the subject of special attention because of its close relation to the extended amygdala and distinctive response to antipsychotic and psychoactive drugs.

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