|
| | |
|
J Neuropsychiatry Clin Neurosci 1997; 9:568-573
Copyright © 1997 by American Neuropsychiatric Association
Probing striatal function in obsessive-compulsive disorder: a PET study of implicit sequence learning
SL Rauch, CR Savage, NM Alpert, D Dougherty, A Kendrick, T Curran, HD Brown, P Manzo, AJ Fischman and MA Jenike
Massachusetts General Hospital, Charlestown 02129, USA.
Positron emission tomography was employed to contrast the brain activation
pattern in patients with obsessive-compulsive disorder (OCD) to that of
matched control subjects while they performed an implicit learning task.
Although patients and control subjects evidenced comparable learning,
imaging data from control subjects indicated bilateral inferior striatal
activation, whereas OCD patients did not activate right or left inferior
striatum and instead showed bilateral medial temporal activation. The
findings further implicate corticostriatal dysfunction in
obsessive-compulsive disorder. Furthermore, when OCD patients are
confronted with stimuli that call for recruitment of corticostriatal
systems, they instead appear to access brain regions normally associated
with explicit (conscious) information processing.
This article has been cited by other articles:
|
|
|
|
 
P. R. Szeszko, C. Christian, F. MacMaster, T. Lencz, Y. Mirza, S. P. Taormina, P. Easter, M. Rose, G.A. Michalopoulou, and D. R. Rosenberg
Gray Matter Structural Alterations in Psychotropic Drug-Naive Pediatric Obsessive-Compulsive Disorder: An Optimized Voxel-Based Morphometry Study
Am J Psychiatry,
October 1, 2008;
165(10):
1299 - 1307.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Valerius, A. Lumpp, A.-K. Kuelz, T. Freyer, and U. Voderholzer
Reversal Learning as a Neuropsychological Indicator for the Neuropathology of Obsessive Compulsive Disorder? A Behavioral Study
J Neuropsychiatry Clin Neurosci,
May 1, 2008;
20(2):
210 - 218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Woolley, I. Heyman, M. Brammer, I. Frampton, P. K. McGuire, and K. Rubia
Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory control
The British Journal of Psychiatry,
January 1, 2008;
192(1):
25 - 31.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Wagner, H. Aizenstein, V. K. Venkatraman, J. Fudge, J. C. May, L. Mazurkewicz, G. K. Frank, U. F. Bailer, L. Fischer, V. Nguyen, et al.
Altered Reward Processing in Women Recovered From Anorexia Nervosa
Am J Psychiatry,
December 1, 2007;
164(12):
1842 - 1849.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. Remijnse, M. M. A. Nielen, A. J. L. M. van Balkom, D. C. Cath, P. van Oppen, H. B. M. Uylings, and D. J. Veltman
Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder.
Arch Gen Psychiatry,
November 1, 2006;
63(11):
1225 - 1236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. A. van den Heuvel, D. J. Veltman, H. J. Groenewegen, M. P. Witter, J. Merkelbach, D. C. Cath, A. J. L. M. van Balkom, P. van Oppen, and R. van Dyck
Disorder-Specific Neuroanatomical Correlates of Attentional Bias in Obsessive-compulsive Disorder, Panic Disorder, and Hypochondriasis
Arch Gen Psychiatry,
August 1, 2005;
62(8):
922 - 933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. A. van den Heuvel, D. J. Veltman, H. J. Groenewegen, D. C. Cath, A. J. L. M. van Balkom, J. van Hartskamp, F. Barkhof, and R. van Dyck
Frontal-Striatal Dysfunction During Planning in Obsessive-Compulsive Disorder
Arch Gen Psychiatry,
March 1, 2005;
62(3):
301 - 309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Martis, C. I. Wright, K. G. McMullin, L. M. Shin, and S. L. Rauch
Functional Magnetic Resonance Imaging Evidence for a Lack of Striatal Dysfunction During Implicit Sequence Learning in Individuals With Animal Phobia
Am J Psychiatry,
January 1, 2004;
161(1):
67 - 71.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Deckersbach, C. R. Savage, T. Curran, A. Bohne, S. Wilhelm, L. Baer, M. A. Jenike, and S. L. Rauch
A Study of Parallel Implicit and Explicit Information Processing in Patients With Obsessive-Compulsive Disorder
Am J Psychiatry,
October 1, 2002;
159(10):
1780 - 1782.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R. Szeszko, D. Robinson, J. Ma. J. Alvir, R. M. Bilder, T. Lencz, M. Ashtari, H. Wu, and B. Bogerts
Orbital Frontal and Amygdala Volume Reductions in Obsessive-compulsive Disorder
Arch Gen Psychiatry,
October 1, 1999;
56(10):
913 - 919.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1997
American Neuropsychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
