J Neuropsychiatry Clin Neurosci 1997; 9:579-583
Copyright © 1997 by American Neuropsychiatric Association
Incidence of extrapyramidal syndromes in AIDS patients and a comparison group of medically ill inpatients
G Ramachandran, L Glickman, J Levenson and C Rao
Department of Psychiatry, State University of New York Health Science Center at Brooklyn, USA.
The authors retrospectively reviewed the charts of 29 inpatients with AIDS
and 24 medically ill inpatients, all of whom were exposed to neuroleptics.
Results adjusted for age, gender, type and dosage of neuroleptic, and
extrapyramidal prophylaxis indicated that inpatients with AIDS were 7 times
more likely to develop extrapyramidal syndromes (EPS) from neuroleptics
than the comparison group of medically ill inpatients. Possible
neuroanatomic, neuropathologic, and neurochemical reasons for the
vulnerability of patients with AIDS to EPS are reviewed.
