|
| | |
|
J Neuropsychiatry Clin Neurosci 1992; 4:134-139
Copyright © 1992 by American Neuropsychiatric Association
Reliability, validity, and clinical correlates of apathy in Parkinson's disease
SE Starkstein, HS Mayberg, TJ Preziosi, P Andrezejewski, R Leiguarda and RG Robinson
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.
The authors examined a consecutive series of 50 patients for the presence
of apathy, depression, anxiety, and neuropsychological deficits using a
neuropsychological battery that included a recently designed apathy scale.
This scale was found to be reliable and valid in the diagnosis of apathy in
patients with PD. Of patients in the study, 12% showed apathy as their
primary psychiatric problem, and 30% were both apathetic and depressed.
Patients with apathy (with or without depression), showed significantly
more deficits in both tasks of verbal memory and time-dependent tasks.
Results suggest that apathy is a frequent finding in PD, is significantly
associated with specific cognitive impairments, and may have a different
mechanism than depression.
This article has been cited by other articles:
|
|
|
|
 
L. Schmidt, B. F. d'Arc, G. Lafargue, D. Galanaud, V. Czernecki, D. Grabli, M. Schupbach, A. Hartmann, R. Levy, B. Dubois, et al.
Disconnecting force from money: effects of basal ganglia damage on incentive motivation
Brain,
May 1, 2008;
131(5):
1303 - 1310.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. K. Fellows and M. J. Farah
The Role of Ventromedial Prefrontal Cortex in Decision Making: Judgment under Uncertainty or Judgment Per Se?
Cereb Cortex,
November 1, 2007;
17(11):
2669 - 2674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Weintraub, D. Taraborelli, K. H. Morales, J. E. Duda, I. R. Katz, and M. B. Stern
Escitalopram for Major Depression in Parkinson's Disease: An Open-Label, Flexible-Dosage Study
J Neuropsychiatry Clin Neurosci,
August 1, 2006;
18(3):
377 - 383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Kirsch-Darrow, H. F. Fernandez, M. Marsiske, M. S. Okun, and D. Bowers
Dissociating apathy and depression in Parkinson disease.
Neurology,
July 11, 2006;
67(1):
33 - 38.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Levy and B. Dubois
Apathy and the Functional Anatomy of the Prefrontal Cortex-Basal Ganglia Circuits
Cereb Cortex,
July 1, 2006;
16(7):
916 - 928.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P Sockeel, K Dujardin, D Devos, C Deneve, A Destee, and L Defebvre
The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: validation in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
May 1, 2006;
77(5):
579 - 584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Weintraub, M. S. Cary, M. B. Stern, D. Taraborelli, and I. R. Katz
Daily Affect in Parkinson Disease Is Responsive to Life Events and Motor Symptoms
Am J Geriatr Psychiatry,
February 1, 2006;
14(2):
161 - 168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pessiglione, V. Czernecki, B. Pillon, B. Dubois, M. Schupbach, Y. Agid, and L. Tremblay
An Effect of Dopamine Depletion on Decision-making: The Temporal Coupling of Deliberation and Execution
J. Cogn. Neurosci.,
December 1, 2005;
17(12):
1886 - 1896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C Meyniel, S Rivaud-Pechoux, P Damier, and B Gaymard
Saccade impairments in patients with fronto-temporal dementia
J. Neurol. Neurosurg. Psychiatry,
November 1, 2005;
76(11):
1581 - 1584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V Czernecki, B Pillon, J L Houeto, M L Welter, V Mesnage, Y Agid, and B Dubois
Does bilateral stimulation of the subthalamic nucleus aggravate apathy in Parkinson's disease?
J. Neurol. Neurosurg. Psychiatry,
June 1, 2005;
76(6):
775 - 779.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Kuoppamaki, J C Rothwell, R G Brown, N Quinn, K P Bhatia, and M Jahanshahi
Parkinsonism following bilateral lesions of the globus pallidus: performance on a variety of motor tasks shows similarities with Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
April 1, 2005;
76(4):
482 - 490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. van Reekum, D. T. Stuss, and L. Ostrander
Apathy: Why Care?
J Neuropsychiatry Clin Neurosci,
February 1, 2005;
17(1):
7 - 19.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Sienkiewicz-Jarosz, A Scinska, W Kuran, D Ryglewicz, A Rogowski, E Wrobel, A Korkosz, A Kukwa, W Kostowski, and P Bienkowski
Taste responses in patients with Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
January 1, 2005;
76(1):
40 - 46.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Seltzer, P. Zolnouni, M. Nunez, R. Goldman, D. Kumar, J. Ieni, S. Richardson, and for the Donepezil "402" Study Group
Efficacy of Donepezil in Early-Stage Alzheimer Disease: A Randomized Placebo-Controlled Trial
Arch Neurol,
December 1, 2004;
61(12):
1852 - 1856.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Al-Adawi, A. S.S. Dorvlo, D. T. Burke, C. C. Huynh, L. Jacob, R. Knight, M. K. Shah, and A. Al-Hussaini
Apathy and Depression in Cross-Cultural Survivors of Traumatic Brain Injury
J Neuropsychiatry Clin Neurosci,
November 1, 2004;
16(4):
435 - 442.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R E Ready, J Friedman, J Grace, and H Fernandez
Testosterone deficiency and apathy in Parkinson's disease: a pilot study
J. Neurol. Neurosurg. Psychiatry,
September 1, 2004;
75(9):
1323 - 1326.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Weintraub, P. J. Moberg, J. E. Duda, I. R. Katz, and M. B. Stern
Recognition and Treatment of Depression in Parkinson's Disease
J Geriatr Psychiatry Neurol,
September 1, 2003;
16(3):
178 - 183.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. S. Marin, M. A. Butters, B. H. Mulsant, B. G. Pollock, and C. F. Reynolds III
Apathy and Executive Function in Depressed Elderly
J Geriatr Psychiatry Neurol,
June 1, 2003;
16(2):
112 - 116.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G C Pluck and R G Brown
Apathy in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
December 1, 2002;
73(6):
636 - 642.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. CHATTERJEE and S. FAHN
Methylphenidate Treats Apathy in Parkinson's Disease
J Neuropsychiatry Clin Neurosci,
November 1, 2002;
14(4):
461 - 462.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Thompson, J. S. Snowden, D. Craufurd, and D. Neary
Behavior in Huntington's Disease: Dissociating Cognition-Based and Mood-Based Changes
J Neuropsychiatry Clin Neurosci,
February 1, 2002;
14(1):
37 - 43.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Starkstein, G. Petracca, E. Chemerinski, and M. Merello
Prevalence and correlates of parkinsonism in patients with primary depression
Neurology,
August 14, 2001;
57(3):
553 - 555.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Starkstein, G. Petracca, E. Chemerinski, and J. Kremer
Syndromic Validity of Apathy in Alzheimer's Disease
Am J Psychiatry,
June 1, 2001;
158(6):
872 - 877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. L. Lopez, S. Zivkovic, G. Smith, J. T. Becker, C. C. Meltzer, and S. T. DeKosky
Psychiatric Symptoms Associated With Cortical-Subcortical Dysfunction in Alzheimer's Disease
J Neuropsychiatry Clin Neurosci,
February 1, 2001;
13(1):
56 - 60.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. Marsh
Neuropsychiatric Aspects of Parkinson's Disease
Psychosomatics,
February 1, 2000;
41(1):
15 - 23.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. Aarsland, J. P Larsen, N. G. Lim, C. Janvin, K. Karlsen, E. Tandberg, and J. L Cummings
Range of neuropsychiatric disturbances in patients with Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
October 1, 1999;
67(4):
492 - 496.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Kuzis, L. Sabe, C. Tiberti, F. Dorrego, and S. E. Starkstein
Neuropsychological correlates of apathy and depression in patients with dementia
Neurology,
April 1, 1999;
52(7):
1403 - 1403.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
W. J.G. Hoogendijk, I.E. C. Sommer, G. Tissingh, D. J.H. Deeg, and E.Ch. Wolters
Depression in Parkinson's Disease: The Impact of Symptom Overlap on Prevalence
Psychosomatics,
October 1, 1998;
39(5):
416 - 421.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
I. Litvan, J. S. Paulsen, M. S. Mega, and J. L. Cummings
Neuropsychiatric Assessment of Patients With Hyperkinetic and Hypokinetic Movement Disorders
Arch Neurol,
October 1, 1998;
55(10):
1313 - 1319.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Masterman, A. DeSalles, R. W. Baloh, R. Frysinger, D. Foti, E. Behnke, C. Cabatan-Awang, A. Hoetzel, P. M. Intemann, L. Fairbanks, et al.
Motor, Cognitive, and Behavioral Performance Following Unilateral Ventroposterior Pallidotomy for Parkinson Disease
Arch Neurol,
September 1, 1998;
55(9):
1201 - 1208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Levy, J. L. Cummings, L. A. Fairbanks, D. Masterman, B. L. Miller, A. H. Craig, J. S. Paulsen, and I. Litvan
Apathy Is Not Depression
J Neuropsychiatry Clin Neurosci,
August 1, 1998;
10(3):
314 - 319.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. A. Castellon, C. H. Hinkin, S. Wood, and K. T. Yarema
Apathy, Depression, and Cognitive Performance in HIV-1 Infection
J Neuropsychiatry Clin Neurosci,
August 1, 1998;
10(3):
320 - 329.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J S Rubinsztein, D C Rubinsztein, S Goodburn, and A J Holland
Apathy and hypersomnia are common features of myotonic dystrophy
J. Neurol. Neurosurg. Psychiatry,
April 1, 1998;
64(4):
510 - 515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Okada, S. Kobayashi, S. Yamagata, K. Takahashi, and S. Yamaguchi
Poststroke Apathy and Regional Cerebral Blood Flow
Stroke,
December 1, 1997;
28(12):
2437 - 2441.
[Abstract]
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1992
American Neuropsychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
