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J Neuropsychiatry Clin Neurosci 1995; 7:476-484
Copyright © 1995 by American Neuropsychiatric Association
The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease
DL Sultzer, ME Mahler, MA Mandelkern, JL Cummings, WG Van Gorp, CH Hinkin and MA Berisford
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, USA.
Cognitive and noncognitive psychiatric symptoms were systematically
evaluated in 21 patients with Alzheimer's disease by using the
Neurobehavioral Rating Scale. Regional cerebral metabolic activity was
measured in each patient by [18F]fluorodeoxyglucose PET. Significant
correlations emerged between global cortical metabolic activity and the
Agitation/Disinhibition factor score, Cognition factor score, and total
score. Relationships between noncognitive symptoms and metabolic activity
were regionally specific, with significant correlations between
Agitation/Disinhibition factor score and metabolism in the frontal and
temporal lobes, between Psychosis factor score and metabolism in the
frontal lobe, and between Anxiety/Depression factor score and metabolism in
the parietal lobe. These results suggest that psychiatric symptoms are
fundamental expressions of the cortical dysfunction of Alzheimer's disease.
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