Repetitive Transcranial Magnetic Stimulation or Venlafaxine-Induced Mania?
Venlafaxine has been reported to induce mood-switching in patients with bipolar depression and in a few with unipolar depression.4 It is interesting to note that the time period from the introduction or the dose increment of venlafaxine to the induction of the manic or hypomanic episode ranged from 6 days to several weeks.4 Therefore, it is likely that the switch in the Chang et al.1 case was due to venlafaxine, rather than rTMS treatment.
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